Pep Guardiola’s side have a tough away tie to get through if they wish to progress to the last four, while Borussia Dortmund play Hoffenheim
Bayer Leverkusen will host Bayern Munich in the pick of the ties for the DFB-Pokal quarter-finals.
Holders Bayern will be eager for a repeat of the 5-0 win over Hamburg that earned them a place in last season’s semis, while Leverkusen are looking to go a step further than they did last term.
Borussia Dortmund – runners-up to Bayern in 2014 – are at home to Hoffenheim and Wolfsburg welcome Freiburg.
In the round’s remaining tie, third-tier leaders Arminia Bielefeld host Borussia Monchengladbach.
The fixtures will be played on April 7 and 8.
Draw in full:
Bayer Leverkusen v Bayern Munich
Borussia Dortmund v Hoffenheim
Wolfsburg v Freiburg
Arminia Bielefeld v Borussa Monchengladbach